anaesthetic

https://doi.org/10.1351/goldbook.A00317
Substance which produces loss of feeling or sensation: general anaesthetic produces loss of consciousness; local or regional anaesthetic renders a specific area insensible to pain.
Source:
PAC, 1993, 65, 2003. 'Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)' on page 2013 (https://doi.org/10.1351/pac199365092003)