The process of partial or total alteration of the native structure of a macromolecule resulting from the loss of tertiary or tertiary and
secondary structure that is a consequence of the disruption of stabilizing weak bonds. Denaturation can occur when
proteins and
nucleic acids are subjected to elevated temperature or to extremes of pH, or to non-physiological concentrations of
salt, organic solvents, urea or other chemical agents.
Source:
PAC, 1992, 64, 143
(Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992))
on page 151
PAC, 1994, 66, 2587
(Glossary of bioanalytical nomenclature - Part 1: General terminology, body fluids, enzymology, immunology (IUPAC Recommendations 1994))
on page 2593
