IUPAC > Gold Book > alphabetical index > F > feed-back inhibition (end product inhibition) in biotechnology


feed-back inhibition (end product inhibition)

in biotechnology
A metabolic control mechanism in which the end product of a biochemical sequence is able to inhibit the activity of an early enzyme in the sequence, thereby controlling the metabolic flux through this pathway. As an example, isoleucine controls its own synthesis by inhibiting threonine deaminase; adenosine 5-triphosphate (ATP) and citrate control glycolysis by inhibiting phosphofructokinase.
PAC, 1992, 64, 143 (Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)) on page 154
Interactive Link Maps
First LevelSecond LevelThird Level
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. doi:10.1351/goldbook.
Last update: 2014-02-24; version: 2.3.3.
DOI of this term: doi:10.1351/goldbook.F02333.
Original PDF version: http://www.iupac.org/goldbook/F02333.pdf. The PDF version is out of date and is provided for reference purposes only. For some entries, the PDF version may be unavailable.
Current PDF version | Version for print | History of this term