A
kinetic isotopic effect observed when a single substrate, in which the isotopic atoms occupy equivalent reactive positions, reacts to produce a non-statistical distribution of
isotopomeric products. In such a case the
isotope effect will favour the pathway with lower
force constants for displacement of the isotopic nuclei in the
transition state.
Source:
PAC, 1994, 66, 1077
(Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994))
on page 1130
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
doi:10.1351/goldbook.
