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leader sequence

in biotechnology

Also contains definition of: signal sequence

  1. A polynucleotide region between promoter and structural gene, necessary for the correct transcription of DNA into mRNA.
  2. An N-terminal extension of polypeptides (also known as the signal sequence) which is necessary for the transport of the protein into or through the membrane or for its secretion into the extracellular medium.
Source:
PAC, 1992, 64, 143 (Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)) on page 158
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Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. doi:10.1351/goldbook.
Last update: 2014-02-24; version: 2.3.3.
DOI of this term: doi:10.1351/goldbook.L03491.
Original PDF version: http://www.iupac.org/goldbook/L03491.pdf. The PDF version is out of date and is provided for reference purposes only. For some entries, the PDF version may be unavailable.
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