Goldbook title
IUPAC > Gold Book > alphabetical index > C > cooperativity
Gold G Icon
Indexes Download


Interaction between the substrate binding sites of an allosteric enzyme. Binding of a substrate molecule to one binding site changes the affinity of the binding sites on the other subunits (cf. allosteric enzymes) to the substrate by induction of a conformation change at the other binding sites. Cooperative enzymes typically display a sigmoid (S-shaped) plot of the reaction rate against substrate concentration.
PAC, 1992, 64, 143 (Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)) on page 151
Interactive Link Maps
First Level Second Level Third Level
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
Last update: 2014-02-24; version: 2.3.3.
DOI of this term:
Original PDF version: The PDF version is out of date and is provided for reference purposes only. For some entries, the PDF version may be unavailable.
Current PDF version | Version for print | History of this term