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in toxicology
  1. Volume of blood or plasma or mass of an organ effectively cleared of a substance by elimination (metabolism and excretion) divided by time of elimination.
    Total clearance is the sum of the clearances of each eliminating organ or tissue for a given substance.
  2. (in pulmonary toxicology) Volume or mass of lung cleared divided by time of elimination; used qualitatively to describe removal of any inhaled substance which deposits on the lining surface of the lung.
  3. (in renal toxicology) Quantification of the removal of a substance by the kidneys by the processes of filtration and secretion; clearance is calculated by relating the rate of renal excretion to the plasma concentration.
See also: clearance, Δ V Δ t
PAC, 2004, 76, 1033 (Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003)) on page 1045
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IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
Last update: 2014-02-24; version: 2.3.3.
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