A metabolic control mechanism in which the end product of a biochemical sequence
is able to inhibit the activity of an early enzyme
in the sequence
, thereby controlling the metabolic flux through this pathway. As an example, isoleucine
controls its own synthesis by inhibiting threonine deaminase; adenosine 5-triphosphate
(ATP) and citrate control glycolysis by inhibiting phosphofructokinase.
PAC, 1992, 64, 143
(Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992))
on page 154
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by
A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997).
XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic,
J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. https://doi.org/10.1351/goldbook