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ligases (synthetases)

Enzymes that catalyse the ligation of two molecules with concomitant hydrolysis of the pyrophosphate bond in adenosine 5'-triphosphate (ATP) or a similar triphosphate, forming C–C , C–O , C–S , P–O or C–N bonds. In recombinant DNA technology, ligases covalently join together two sequences of DNA (e.g. hostDNA and foreign DNA) by a phosphodiester bond.
PAC, 1992, 64, 143 (Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)) on page 159
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IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
Last update: 2014-02-24; version: 2.3.3.
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