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photoaffinity labelling

Acronym: PAL

Technique by which a photochemically reactive molecular entity, specifically associated with a biomolecule, is photo-excited in order to covalently attach a label to the biomolecule, usually via intermediates. Identification of the resulting photo-crosslinked product provides structural information on the protein′s binding site.
  1. Technique widely used for identifying in general ligand-receptor interactions in biological macromolecules and in particular the binding site within proteins.
  2. Typical examples are nitrenes, carbenes, ketone excited states, cations and radicals.
PAC, 2007, 79, 293 (Glossary of terms used in photochemistry, 3rd edition (IUPAC Recommendations 2006)) on page 383
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IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
Last update: 2014-02-24; version: 2.3.3.
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