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phase I reaction

Enzymic modification of a substance by oxidation, reduction, hydrolysis, hydration, dehydrochlorination, or other reactions catalyzed by enzymes of the cytosol, of the endoplasmic reticulum (microsomal enzymes) or of other cell organelles.
Source:
PAC, 2004, 76, 1033 (Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003)) on page 1064
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IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. https://doi.org/10.1351/goldbook.
Last update: 2014-02-24; version: 2.3.3.
DOI of this term: https://doi.org/10.1351/goldbook.PT06836.
Original PDF version: http://www.iupac.org/goldbook/PT06836.pdf. The PDF version is out of date and is provided for reference purposes only. For some entries, the PDF version may be unavailable.
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