adverse effect

https://doi.org/10.1351/goldbook.AT06809
Change in biochemistry, @MT07285@, physiology, growth, development, or lifespan of an organism which results in impairment of functional capacity or impairment of capacity to compensate for additional stress or increase in susceptibility to other environmental influences.
Source:
PAC, 2004, 76, 1033. (Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003)) on page 1038 [Terms] [Paper]