photoaffinity labelling
Technique by which a photochemically reactive molecular entity, specifically associated with a biomolecule, is photo-excited in order to covalently attach a label to the biomolecule, usually via intermediates. Identification of the resulting photo-crosslinked product provides structural information on the protein′s binding site.
  1. Technique widely used for identifying in general ligand-@RT06841@ interactions in biological macromolecules and in particular the @B00649@ within @P04898@.
  2. Typical examples are @N04145@, @C00806@, ketone excited states, cations and radicals.
PAC, 2007, 79, 293. 'Glossary of terms used in photochemistry, 3rd edition (IUPAC Recommendations 2006)' on page 383 (