feed-back inhibition (end product inhibition)

in biotechnology
A metabolic control mechanism in which the end product of a biochemical @[email protected] is able to inhibit the activity of an early @[email protected] in the @[email protected], thereby controlling the metabolic flux through this pathway. As an example, isoleucine controls its own synthesis by inhibiting threonine deaminase; adenosine 5-triphosphate (ATP) and citrate control glycolysis by inhibiting phosphofructokinase.
PAC, 1992, 64, 143. (Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)) on page 154 [Terms] [Paper]