A metabolic control mechanism in which the end product of a biochemical @[email protected] is able to inhibit the activity of an early @[email protected] in the @[email protected], thereby controlling the metabolic flux through this pathway. As an example, isoleucine controls its own synthesis by inhibiting threonine deaminase; adenosine 5-triphosphate (ATP) and citrate control glycolysis by inhibiting phosphofructokinase.