Metabolic formation of a highly toxic compound from one that is relatively non-toxic (bioactivation), often leading to death of affected cells. Synonymous with suicide metabolism.
Source: PAC, 1993, 65, 2003. (Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)) on page 2063 [Terms] [Paper]
Citation: 'lethal synthesis' in IUPAC Compendium of Chemical Terminology, 3rd ed. International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. https://doi.org/10.1351/goldbook.L03501 RISBibTexEndNote