lowest observed adverse effect level (LOAEL)

Lowest concentration or amount of a substance, found by experiment or observation, which causes an adverse alteration of @[email protected], functional capacity, growth, development, or life span of a target organism distinguishable from normal (control) organisms of the same species and @[email protected] under defined conditions of @[email protected]
PAC, 1993, 65, 2003. (Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)) on page 2065 [Terms] [Paper]
PAC, 2001, 73, 993. (Risk assessment for occupational exposure to chemicals. A review of current methodology (IUPAC Technical Report)) on page 1023 [Terms] [Paper]
This definition supersedes an earlier definition of lowest-observed-adverse-effect-level.