Lipophilicity represents the affinity of a molecule or a @M03968@ for a @L03572@ environment. It is commonly measured by its distribution behaviour in a biphasic system, either liquid-liquid (e.g., @P04437@ in 1-octanol/water) or solid-liquid (retention on reversed-phase high-performance liquid @C01075@ (RP-HPLC) or @T06346@ (TLC) system).
PAC, 1972, 31, 577. (Manual of Symbols and Terminology for Physicochemical Quantities and Units, Appendix II: Definitions, Terminology and Symbols in Colloid and Surface Chemistry) on page 607 [Terms] [Paper]
PAC, 1994, 66, 1077. (Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)) on page 1123 [Terms] [Paper]
PAC, 1997, 69, 1137. (Glossary of terms used in computational drug design (IUPAC Recommendations 1997)) on page 1145 [Terms] [Paper]