NIH shift
The @[email protected] hydrogen @[email protected] which can be observed in enzymatic and chemical hydroxylations of aromatic rings. It is evidenced by appropriate @[email protected] @[email protected], i.e.
In enzymatic reactions the NIH shift is generally thought to derive from the @[email protected] of arene oxide intermediates, but other pathways have been suggested. (NIH stands for U.S. National Institutes of Health where the shift was discovered.)
PAC, 1994, 66, 1077. (Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)) on page 1145 [Terms] [Paper]