primary isotope effect

https://doi.org/10.1351/goldbook.P04831
A @K03405@ attributable to isotopic substitution of an atom to which a bond is made or broken in the @R05139@ or in a @P04810@ step of a specified reaction. The corresponding @I03327-1@ on the @E02177@ of a reaction in which one or more bonds to isotopic atoms are broken, is called a 'primary @I03327-2@'.
See also:
secondary isotope effect
Source:
PAC, 1994, 66, 1077. (Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)) on page 1130 [Terms] [Paper]
Cite as: IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). Online version (2019-) created by S. J. Chalk. ISBN 0-9678550-9-8. https://doi.org/10.1351/goldbook.
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Last revised: February 24, 2014