https://doi.org/10.1351/goldbook.P04831
A @[email protected] attributable to isotopic substitution of an atom to which a bond is made or broken in the @[email protected] or in a @[email protected] step of a specified reaction. The corresponding @[email protected] on the @[email protected] of a reaction in which one or more bonds to isotopic atoms are broken, is called a 'primary @[email protected]'.
See also:
secondary isotope effect