pro-R, pro-S

https://doi.org/10.1351/goldbook.P04889
A @S05981@ group c (as in tetrahedral Xabc2) is described as pro-R if, when it is arbitrarily assigned @C01082@ over the other @S05981@ group c, the configuration of the thus generated @C01057@ centre is assigned the @S05976@ R. The other group c is then described as pro-S. This method for distinguishing between @S05981@ groups can be applied to other kinds of prochiral molecular entities or @P04859@ parts of molecular entities considered on their own.
See:
prochirality centre
Source:
PAC, 1996, 68, 2193. (Basic terminology of stereochemistry (IUPAC Recommendations 1996)) on page 2214 [Terms] [Paper]
Cite as: IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). Online version (2019-) created by S. J. Chalk. ISBN 0-9678550-9-8. https://doi.org/10.1351/goldbook.
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Last revised: February 24, 2014