systemic effect

https://doi.org/10.1351/goldbook.ST06802
Consequence that is either of a generalized nature or that occurs at a site distant from the point of entry of a substance.
Source:
PAC, 2004, 76, 1033. (Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003)) on page 1072 [Terms] [Paper]