The limit of detection, expressed as the concentration,
or the quantity,
is derived from the smallest
, that can be detected with reasonable certainty
for a given analytical procedure.
The value of
is given by the equation
is the mean of the blank measures,
is the standard deviation
of the blank measures, and
is a numerical factor chosen according to the confidence level
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by
A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997).
XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic,
J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. https://doi.org/10.1351/goldbook